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Clinical trials Medicine Skepticism/critical thinking

The Cochrane mask fiasco: Does EBM predispose to COVID contrarianism?

Earlier this month the Cochrane Collaborative was forced to walk back the conclusions of a review by Tom Jefferson et al that had been spun in the media as proving that “masks don’t work.” Tom Jefferson himself has been problematic about vaccines for a long time, but the rot goes deeper. What is it about the evidence-based medicine paradigm that results in misleading conclusions?

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Antivaccine nonsense Bad science Clinical trials Medicine

Peter Doshi vs. COVID-19 vaccines, the latest round

BMJ Senior Editor Peter Doshi published a preprint misleadingly “reanalyzing” phase 3 clinical trials to falsely conclude that mRNA vaccines to cause more harm than good. I sense…p-hacking. That, and comparing apples to oranges.

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Clinical trials Homeopathy Medicine Quackery

Why are so many clinical trials of homeopathy “positive”?

Homeopathy is The One Quackery To Rule Them All. Why, then, can homeopaths seemingly cite so many “positive” randomized clinical trials to support it?

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Clinical trials Complementary and alternative medicine Medicine Science Skepticism/critical thinking

The revenge of the son of the myth of "placebos without deception"

Back when advocates of “alternative” medicine were busily trying to legitimize their quackery by first renaming it “complementary and alternative medicine” (CAM), long before CAM “evolved” into “integrative medicine,” they really believed that if their favorite woo were to be studied scientifically it would be shown to be efficacious. Thus was born the Office of […]

Categories
Clinical trials Medicine Science Skepticism/critical thinking

What next for the randomized controlled clinical trial?

One of the most frequent complaints about evidence-based medicine (EBM), in contrast to science-based medicine (SBM), is its elevation of the randomized clinical trial as the be-all and end-all for clinical evidence for an intervention for a particular disease or condition. Unknown but enormous quantities of “digital ink” have been spilled explaining this distinction right […]

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