If there’s one thing that burns me about so-called “complementary and alternative medicine” (CAM) clinical trials, it’s how unethical many of them are. This is particularly true for trials that test modalities that, on the basic science grounds alone, can be dismissed as so highly implausible and with such a low prior probability of success […]
Category: Science
Every so often, real life intrudes on blogging, preventing the creation of fresh Insolence, at least Insolence of the quality that you’ve come to expect. This is one of those times, thanks to R01 deadlines. So enjoy this bit of Classic Insolence from back in September 2007 that, shockingly, as far as I can tell […]
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It just occurred to me that it’s been a long, long time since I’ve done this, but how about an open thread to while away the time until the NIH R01 grant application is submitted, and that gloriously irritating and outrageously beautiful not-so-Respectful Insolence that you all crave can come roaring back with a vengeance? […]
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Could it be that correlation does equal causation? I wonder…
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A critical aspect of both evidence-based medicine (EBM) and science-based medicine (SBM) is the randomized clinical trial. Ideally, particularly for conditions with a large subjective component in symptomatology, the trial should be randomized, double-blind, and placebo-controlled. As Kimball Atwood pointed out just last week (me too), in EBM, scientific prior probability tends to be discounted […]
