Complementary and alternative medicine Medicine Paranormal Pseudoscience Quackery Skepticism/critical thinking

Alternative medicine for premature ejaculation? Surprise, surprise! It doesn’t work.

I must admit that the last couple of weeks have been rather grim here on the old blog. Betweemn Donald Trump’s White House spewing , an unfortunate patient embracing quackery, pseudoscience at the VA, and more. So it is that I feel as though it might not be a bad idea to step back for a day, to look into an acupuncture “study” that’s been making the rounds in the media. Oddly enough, I remember it showing up a week ago and meant to discuss it then. So I’m glad that I saw a new news story on it in —where else?—The Daily Mail in the form of an article entitled Forget Viagra – acupuncture could stave off erectile dysfunction, experts claim.

As soon as I read the article, I laughed. It was so sloppily done that the title didn’t even match what the study was about, saying “Acupuncture could help men with premature ejaculation, a new report claims..” So what was the paper about, erectile dysfunction or premature ejaculation? It turns out that it’s about premature ejaculation. Darn. There go the boner jokes. Oh, well, there is this:

Acupuncture could help men with premature ejaculation, a new report claims.

The improvements were small, and the studies were of varying quality.
However, researchers in the UK concluded various alternative treatments – including acupuncture, Chinese herbal medicine, Ayurvedic herbal medicine and a Korean topical cream – have significant desirable effects.

Experts claim the finding could bring welcome relief for men who have not got Viagra out of embarrassment, or are marred by a months-long wait to see a doctor.

‘It’s important to evaluate the evidence for other therapies,’ said lead author Katy Cooper of the University of Sheffield.

‘To our knowledge, this is the first systematic review to assess complementary and alternative medicine for premature ejaculation.

So wait a minute. Is this study about acupuncture and premature ejaculation or is it about more? I was puzzled. So I did what I always do in cases like this. I went to the source, which, I point out, took a bit of effort to find, thanks to the Mail’s failure to link to the actual study. Find it I did (eventually), though, in the form of an article by Cooper et al entitled Complementary and Alternative Medicine for Management of Premature Ejaculation: A Systematic Review. So wait. This is about all CAM for management of premature ejaculation. There go the jokes about sticking needles into men’s nether regions and/or early liftoff. Or not. Or, I could just go for the joke about my never, ever having a problem or needing treatment for something like this.

In any case, it’s important to understand what premature ejaculation is. According to this article, premature ejaculation (PE) is defined as ejaculation within 1 minute (lifelong PE) or 3 minutes (acquired PE), inability to delay ejaculation, and negative personal consequences. I wasn’t familiar with the treatment of PE; so it was of interest for me to read the authors’ summary in the introduction:

Management of PE can involve a range of interventions. These include systemic drug treatments such as selective serotonin reup- take inhibitors (SSRIs), tricyclic antidepressants, phosphodiesterase type 5 inhibitors, and analgesics and topical anesthetic creams and sprays that are applied directly to the penis shortly before inter- course.9,10 Behavioral therapies also can be useful.6,9,11,12 These can include psychosexual or relationship counseling for men and/or couples to address psychological and interpersonal issues that could be contributing to PE. Behavioral therapies also can include physical techniques to help men develop sexual skills to delay ejaculation and improve sexual self-confidence, such as the “stop- start” technique, “squeeze” technique, and sensate focus.6,9,11,12 There are sparse data on whether and for how long effectiveness is maintained after cessation of treatment (drug or behavioral) and whether repeat treatments are effective.

Well, OK, then. That’s a bit more than I wanted to know.

Now, I can understand why men might try quackery if they have problems in the sack. It doesn’t take much searching online to find the veritably panoply of remedies, herbal and otherwise, for PE and erectile dysfunction. That doesn’t even take into account the various products sold as aphrodisiacs. So it makes sense to see what the authors defined as “CAM”:

CAM has been defined by the Cochrane Collaboration as “a broad domain of healing resources that encompasses all health systems, modalities, and practices and their accompanying the- ories and beliefs, other than those intrinsic to the politically dominant health system of a particular society or culture in a given historical period.”15 In addition, many CAM therapies are based on a traditional model of health and well-being, and many (although not all) are designed to treat the whole patient as opposed to a specific condition, whereas some (although not all) involve the use of traditional or natural therapies. Therefore, CAM is defined in this study as therapies for PE that have typically not been provided within conventional Western health care systems and that appear on the list of CAM therapies collated by the Cochrane Collaboration.

In other words, CAM is anything outside of science-based medicine. Yeah, that will do it. They looked for randomized clinical trials, with a study being eligible for inclusion if they compared CAM therapies for management of PE against placebo, waitlist, no treatment, or another therapy or assessed combination treatment with CAM. They also had to include standard measures of PE outcomes, including:

  • Premature Ejaculation Profile (PEP)
  • Index of Premature Ejaculation (IPE)
  • Premature Ejaculation Diagnostic Tool (PEDT)
  • Arabic Index of Premature Ejaculation (AIPE)
  • Chinese Index of Premature Ejaculation–5 (CIPE-5)
  • International Index of Erectile Function (IIEF)

Live and learn. I had no idea there were so many measurement of PE. For instance, one of them mentioned is intravaginal ejaculation latency time (IELT), which, I learned through Googling, frequently measured by couples using a stopwatch. (It seems to me that that would really ruin the mood.) Again, I learned more reading this paper than I probably actually wanted to.

Not surprisingly, the quality of the studies was pretty crappy, too:

The risk of bias within included studies is presented in Table 2. Five studies reported the method of randomization,26, 28, 29, 32, 35 whereas the other five did not report the method but did state that the study was randomized. Allocation concealment was unclear in all studies. Blinding of participants and personnel was reported as being undertaken in five studies.26, 29, 33, 34, 35 Blinding of outcome assessment was unclear in all studies except one,35 which reported that this was blinded. All studies except one35 were considered at low risk of bias for completeness of outcome data, with eight studies including at least 90% of randomized patients in the primary analysis and the two studies of SS cream including 85%34 and 68%,35 respectively. All studies scored a low risk for selective reporting except for one that did not report on IELT.27 Of the nine studies reporting on IELT, this was measured by stopwatch in five studies,26, 28, 29, 34, 35 by questionnaire in one study,32 and the method of IELT assessment was not reported in three studies.30, 31, 33 In summary, all 10 studies were classed as having an overall unclear risk of bias because of unclear reporting of allocation concealment (all 10 studies) and unclear blinding of participants and personnel (five studies).

On to the results. Overall, 2,455 citations were identified through the search strategy chosen, which lead to 14 of them meeting all their criteria. Two of these were studies of Chinese medicine that were excluded because they did not report on IELT or any validated or widely used PE outcome measurement. Two more studies assessing a combination of yoga and pelvic floor exercises were excluded because one was not randomized and the other did not report on IELT or any validated or widely used PE outcome measurement. That left only ten RCTs. Two studies examined acupuncture, five looked at Chinese herbal medicine, one studied Ayurvedic herbal medicine and two of Korean topical ‘severance secret’ cream.

Despite all the news stories I saw about this systematic review emphasizing acupuncture, of the two acupuncture studies examined, one was from Turkey and one from China, each comparing acupuncture with either sham or various drugs used to treat PE. The results were, at best, quite equivocal. Indeed, the best the authors could say was this:

One study compared acupuncture against sham acupuncture (N analyzed = 60) and In summary, the available data indicate that acupuncture might be slightly more effective than placebo (sham) in treating PE, although this is based on only one study of unclear quality.

Yes, the “positive” result found is based on one crappy study. In other words, there’s no good evidence that acupuncture helps PE. This is not surprising, given that there is no physiological reason to think that there would be Basically, what was presented was a grab bag of studies:

The included studies evaluated the effectiveness of acupuncture, Chinese herbal medicine, Ayurvedic herbal medicine, and topical SS cream in improving IELT and other outcomes. Overall risk of bias was unclear in all studies because of unclear allocation concealment and/or blinding. Studies were clinically heterogeneous and stopwatch-measured IELT was reported in only 5 of 10 studies. Acupuncture increased IELT over placebo (one study; MD = 0.55 minute, P = .001). Ayurvedic herbal medicine increased IELT over placebo (one study; MD = 0.80 minute, P = .001). Topical SS cream improved IELT over placebo in two crossover studies (MD = 8.60 minutes, P < .001), although inclusion criteria were broad (IELT < 3 minutes), and there were mild irritant effects in some patients. SSRIs were more effective on IELT than Chinese herbal medicine (three studies; MD = 1.01 minutes, P = .02). However, combination treatment with Chinese medicine plus SSRIs improved IELT over SSRIs alone (two studies; MD = 1.92 minutes, P < .00001) or Chinese medicine alone (two studies; MD = 2.52 minutes, P < .00001). Adverse effects were not consistently assessed but where reported were generally mild. There were sparse data on the potential for drug interactions.

In other words, the results were mixed and pretty unconvincing. Even the Daily Mail article concedes it, stating quite plainly that “The main limitation of the study is the underlying weakness of the studies evaluated” and that “the studies are so different, it’s tough to draw conclusions about the different options.” In the article, the authors dance around this issue quite impressively:

Pragmatically, because there are so many CAM therapies available, it seems unlikely that they will all undergo further evaluation in large-scale studies. Therefore, it might be reasonable to summarize that the CAM therapies reviewed here have some (although limited) evidence for effectiveness in treating PE, and that they might provide another option for patients who favor a mind-body approach or who wish to avoid long-term pharmacologic treatment. It would need to be borne in mind that the effectiveness evidence is not conclusive, and care would need to be taken to monitor for adverse effects and to consider the potential for herb-drug interactions.

No it isn’t reasonable to say that the CAM therapies reviewed “might provide another option for patients,” and the evidence for effectiveness is far less than “not conclusive.” In fact there’s nothing much in this review article to suggest that alternative medicine helps PE.

By Orac

Orac is the nom de blog of a humble surgeon/scientist who has an ego just big enough to delude himself that someone, somewhere might actually give a rodent's posterior about his copious verbal meanderings, but just barely small enough to admit to himself that few probably will. That surgeon is otherwise known as David Gorski.

That this particular surgeon has chosen his nom de blog based on a rather cranky and arrogant computer shaped like a clear box of blinking lights that he originally encountered when he became a fan of a 35 year old British SF television show whose special effects were renowned for their BBC/Doctor Who-style low budget look, but whose stories nonetheless resulted in some of the best, most innovative science fiction ever televised, should tell you nearly all that you need to know about Orac. (That, and the length of the preceding sentence.)

DISCLAIMER:: The various written meanderings here are the opinions of Orac and Orac alone, written on his own time. They should never be construed as representing the opinions of any other person or entity, especially Orac's cancer center, department of surgery, medical school, or university. Also note that Orac is nonpartisan; he is more than willing to criticize the statements of anyone, regardless of of political leanings, if that anyone advocates pseudoscience or quackery. Finally, medical commentary is not to be construed in any way as medical advice.

To contact Orac: [email protected]

31 replies on “Alternative medicine for premature ejaculation? Surprise, surprise! It doesn’t work.”

Two thoughts:
A. I have to imagine any way of measuring effectiveness would either be unreliable, if treatment actually worked, or voyeuristic.

B. Thank you for a lighter post these weeks. Much needed.

Acupuncture gave men about half a minute longer than they had previously, a study showed –claims a picture caption from the Daily Mail article (technically 0.55 minutes from the actual review paper).

Not worth the effort, time or money for a launch delay of only 30 seconds. I’d call this a premature evaluation of CAM on premature ejaculation.

Also, it’s only one study. The other was negative. They got the number by taking the average of 0.55 minutes and 0 minutes.

Well, when I am about to ejaculate I just think about Rich Scopie in a bikini…

This usually buys me a few minutes!

The incidence of PE is estimated to be as high as 30%; a figure that once came as a surprise to me. As a man, it’s not a problem that I have ever heard another man bring up. However, female friends assure me that it’s far more common than men let on, even among younger men.

Years ago, I was asked to search herbal treatments for PE. One of the most dubious and disgusting was a Chinese preparation containing opium. It was dark brown gooey salve that left a stain on well, everything it touched. It also wasn’t very effective, or at least the quality of studies on it was extremely poor.

Alpha blockers, commonly prescribed for lower urinary tract symptoms in men, have a common patient-reported side effect of retrograde ejaculation. Now, there’s a problem I wouldn’t wish on any man. Perhaps not surprisingly, some interest has been shown in low doses of silodosin as a potential treatment for PE. In a recent clinical trial, it appeared to work better and was more tolerable than the SSRI, dapoxetine.

I can hear the jokes already: Is your mercury retrograde, or are you just happy to see me?

In the detailed picture Orac provides for this premature ejaculation posting, why are the needles meticulously placed in a straight line?

I’m no expert but it’s possible the medical professionals may be sending mixed signals to the brain using the straight-line acupuncture method.

Well, it’s better than people sucking up doctor’s time for a non-problem.

I have to imagine any way of measuring effectiveness would either be unreliable, if treatment actually worked, or voyeuristic.

One could always use a structured piece of music. Carmina Burana, say.

PGP @11: I wouldn’t say it’s a non-problem, but I would say that it’s a quality of life problem that could mess with a guy’s head.

Frankly I’m amazed that all these researchers got enough participants. I would have thought this was one of those conditions most men would be unwilling to admit to.

(Unless the researchers promised a cure, which would be super unethical and would totally mess with the data.)

Wasn’t there an episode of CSI where a guy was using topical cocaine to fix his PE?

What I find fascinating is that the reporter is incapable of ascertaining the difference between PE and ED.
That’s about as bad as a reporter writing about CAM and describing “A cam is a rotating or sliding piece in a mechanical linkage used especially in transforming rotary motion into linear motion or vice versa” to explain it.

As one example that I’m familiar with, an individual may take metoprolol, a B1 blocker, to control hypertension and experience ED, but not ever experience PE. A person suffering from metoprolol induced ED could be successfully treated with viagra or similar PDE5 inhibitors and still not experience PE.
A person suffering from PE, if treated with a PDE5 inhibitor would still experience PE, but potentially suffer from priapism, necessitating emergency treatment.

While it may not be reasonable for a reporter to understand all of that, it is reasonable enough to expect a reporter to at least look up PE and ED and know the difference between popping way too early and not being capable of sustaining an erection.
Of course, considering the publication, perhaps it’s enough to be able to expect comprehensible sentences and correct spelling, rather than competency.

The Doors, “Light My Fire’

i know it’s PE not ED, but I’m still going to say this gives a new meaning to the phrase ‘needle dick’.

Too bad it was just a review Orac found, and not the original studies, as I assume Orac did not discover which acupoints supposedly control ejacuation. Could they be in the hands, especially if they’re small?

Did the studies control for the kink level in the subjects? That could account for the difference between the sham and actual group, if the actuals were more uptight the shams were getting too stimulated from a little safe, sane and consensual pain. I hope the researchers were not so unethical as to not supply subjects with a safe word.

i know it’s PE not ED, but I’m still going to say this gives a new meaning to the phrase ‘needle dick’.

Oh, that’s a treatment for priaprism.

I am going to the Pub and be the dart target tonight so be ready when I get home honey.

It must be said… New meaning to the phrase “Needle Dick” or “Pin Prick” So many puns, so little time.

Should have refreshed before posting.. I guess that means I had a premature verbal ejaculation. Maybe some pins in me will fix that.. 😉

Sorry sadmar.

What I find fascinating is that the reporter is incapable of ascertaining the difference between PE and ED.

I imagine the journamalist knows the difference, but if you work for the Daily Fail you write to the insecurities of the readership, not to the facts of the story.

I was just surprised to see that there is a TCM contemporary Chinese scam purporting to delay ejaculation rather than promising boners. Can’t help wondering which parts of which endangered species are involved.

Can’t help wondering which parts of which endangered species are involved.

Cialisaurus Rex bones.
Pity though, I’d not minded if they used eye of newt Gingrich…

Can’t help wondering which parts of which endangered species are involved.

Imma pretty sure that it is narwhal anus.

@Wizrd1 #18

I’ve actually seen a urologist do that to a fellow in the ER. Side effect of Seroquel.

Oy! 😮

One of the hardest lessons to learn in any field of medicine is, “the patient’s illness is not *my* illness” and “it ain’t *my* member/body part” when administering a painful treatment.

Of course, the corollary is, it really, really sucks when it *is* your own illness…

Geez, a fitbit for a penis.
Just what the Internet-of-Things needs… Bluetooth-enabled devices to let every hacker in the known universe know precisely what you are watching when engorgement occurs.


According to this article, premature ejaculation (PE) is defined as ejaculation within 1 minute (lifelong PE) or 3 minutes (acquired PE), inability to delay ejaculation, and negative personal consequences.


Really? You mean, there is something wrong with me?

What do I do?

measured by couples using a stopwatch. (It seems to me that that would really ruin the mood.)

That would depend on your feelings towards Morley Safer. I think that having Mike Wallace suddenly start asking questions would certainly have some impact.

For readers outside the US, there’s a weekly news show called 60 Minutes which begins and ends with a ticking stopwatch. The reporters mentioned above were long time contributors to this show.

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