I hate to do this to Bora again. I really do. I’m also getting tired of blogging all these crappy acupuncture studies. I really am. However, sometimes a skeptic’s gotta do what a skeptic’s gotta do, and this is one of those times. As you may recall, a mere week ago I was disturbed to […]
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THE PAST IS PROLOGUE Location: Central New Jersey, deep within the brick and steel of a secret pharma base. Year: 1999. A shadowy figure dressed in gray, bald, and stroking a white cat enters a nondescript room in the middle of which sits a massive conference table. More than a dozen men and women leap […]
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I’m a cancer surgeon. I started out as a general surgeon, but my passion and scientific interest goaded me into specializing in cancer. Ultimately, I ended up subspecializing even more, ultimately becoming a breast cancer surgeon, but through it all cancer, not just breast cancer, has remained my clinical and scientific passion. So has science-based […]
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A critical aspect of both evidence-based medicine (EBM) and science-based medicine (SBM) is the randomized clinical trial. Ideally, particularly for conditions with a large subjective component in symptomatology, the trial should be randomized, double-blind, and placebo-controlled. As Kimball Atwood pointed out just last week (me too), in EBM, scientific prior probability tends to be discounted […]
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If there’s one thing that burns me about so-called “complementary and alternative medicine” (CAM) clinical trials, it’s how unethical many of them are. This is particularly true for trials that test modalities that, on the basic science grounds alone, can be dismissed as so highly implausible and with such a low prior probability of success […]
