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Bioethics Cancer Clinical trials Medicine Science

Balancing scientific rigor versus patient good in clinical trials

A critical aspect of both evidence-based medicine (EBM) and science-based medicine (SBM) is the randomized clinical trial. Ideally, particularly for conditions with a large subjective component in symptomatology, the trial should be randomized, double-blind, and placebo-controlled. As Kimball Atwood pointed out just last week (me too), in EBM, scientific prior probability tends to be discounted […]

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Humor Science

Researchers versus biostatistics

A friend of mine at work sent this video to me in great amusement. I just hope he wasn’t making a comment on my behavior when it comes to dealing with our biostatisticians. I have, of course, seen investigators approach biostatistians this late in the game. Not that I’ve ever flirted with this sort of […]

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Announcements Skepticism/critical thinking

Drunken Skeptics? Are there any other kinds?

If there’s one area where I’ve been remiss, it’s been in promoting new skeptics groups. Maybe it’s the enormous Orac-ian ego. Maybe it’s sheer laziness. Maybe it’s becoming too engrossed in work and my two blog projects. I will try to rectify that in the future beginning by flogging a new skeptics group from my […]

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Antivaccine nonsense Autism Medicine

SafeMinds swings at Price et al and misses

On the blogging front, I started out this week with a part facetious, part serious, part the highly detailed analysis of a new study of interest that you’ve come to know and love (or hate). The study was Price et al, and it was yet another nail in the coffin of the scientifically discredited notion […]

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Humor Pareidolia Skepticism/critical thinking

Lamest pareidolia ever? Satan appears on a bathroom tile in Budapest

It’s no secret that I’m a bit of a connoisseur of pareidolia. The various shapes and contortions the human mind can impose on clouds, stains, pancakes, trees, toast, Lava lamps, toilet seats, and even medical imaging tests never ceases to amaze me. We are pattern-seeking creatures, and our brains will go to great lengths to […]