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Take that, antivaxers! This is nearly the end…of 2017, that is—with puppies!

It’s the end of the year. So, before I take the rest of the year off, not to return until January 3, I thought I’d end on a happy note. What could be happier than puppies?

As huge of a pain as it was to move the old blog over to this spiffy new setup, there was one advantage other than the spiffy new setup. That advantage was that the three or four weeks of downtime during which I transferred over twelve years worth of material over to the new site taught me that it’s OK to take time off from the blog every now and then. My traffic recovered faster than I thought it would, for one thing. True, it’s still not up to old levels, but I find these days that I don’t really care about my traffic the way I used to; so it doesn’t really bother me. It also means that, in case you haven’t figured it out already, I’m taking this week off—well, except for this post, which will not be about anything medical at all. I always reserve the right to change my mind if something happens between now and January 3 that I cannot resist. However, most years the week between Christmas and New Years is fairly quiet on the quackery front, as it is usually so on the news front; so I’m probably safe. We also will have a houseguest over the New Years Day weekend, which means that I probably won’t manage to post on January 2.

Because it’s the holiday season, I thought I’d do something a little personal. This is Dora:

Dora was my study companion while I was reviewing for my surgery board recertification last month.

She’s a dog my wife and I volunteered to foster and now want to adopt. We picked her up in October. She’s one of the sweetest dogs we’ve ever met. There was a little catch—or should I say surprise?—six and a half weeks ago. Those of you who follow my Facebook feed and maybe those who follow my Twitter feed already know what the catch was. Dora, it turned out when my wife took her to be spayed, was pregnant with eight puppies.

I had never seen a dog give birth before, and it was fascinating to watch. Over the course of five hours or so (from around 3 AM to 8 AM, of course), each puppy came out, and as it did Dora would lick the membranes off frantically. When it was over, there were eight new puppies, four black and four mixed white and black, overall six males and two females.

Dora's puppies
Dora’s puppies, a couple of days old.
Dora's puppies
Don’t blame me for the cat blanket. The dog shelter supplied that for us with a pile of other blankets.

It wasn’t a lot of work at first because the puppies couldn’t walk and only consumed the milk that Dora provided. They were blind and deaf, as puppies are for the first weeks of life. Of course, as anyone who’s ever raised puppies (which now includes us) knows, as they grow, open their eyes, and acquire the ability to walk, things get…interesting. They also have to be introduced to solid food. Right now, at six and a half weeks, the puppies are pretty much weaned, and all that remains is to get them switched over from blended food to solid puppy food, which should happen within the next few days.

When last we weighed them a couple of days ago, they ranged in weight from around 5.7 to 7.3 lbs. Yes, they’re really getting big fast, and it’s hard to believe that a dog as small as Dora carried eight puppies that large! (They were under a pound at birth.) The hilarious thing is that the puppies, who all used to be able to fit on my lap, still seem to think that they are small enough to keep doing it. Here they are on Christmas morning:

And they’re learning to play, having discovered the joys of tug-of-war with each other and chasing various toys and balls:

And, finally, here they are this morning. They’re really becoming active!

Yes, there’s a lot of pee around. One thing we’ve learned from these puppies is that it’s impossible to keep the pen clean for very long and that we just have to roll with it. And there is a lot of pee and poo to clean up, such that even cleaning it three times a day after feeding doesn’t keep up with it. Also, puppies aren’t the least bit concerned about stepping in it and spreading it all over the pen, but, being dogs, instinctively do not poop near their bed area. It kind of strikes me as a metaphor for life, actually.

We’re still going to adopt Dora, but unfortunately we don’t think we can adopt one of the puppies because training a new puppy from scratch and seeing him through his…energetic…years is more sustained work than I think we can handle after this. I have little doubt that these cuties will quickly find forever homes after they go out in pairs to new fosters in a couple of weeks. We’ll be sad when they have to leave and we’ll miss the little buggers (puppy breath and kisses!), but we’ll have our normal life back, no longer regimented to feedings followed by cleaning up copious poop three times a day, and our basement will no longer have that gross sickly sweet smell of puppy poop always hanging in the air. Fortunately, it’s a lot less intense than poop from an adult dog, but it is…different.

Life’s full of surprises, and this one was a doozy. It’s been a hell of a lot of fun. I might have to do it again—after I’m retired and have the time. Maybe by 2030 or a bit later I’ll be able to do this again. In the meantime, here’s proof that I’m not as evil as antivaxers think I am. I love puppies.

NOTE: The shelter for which we’re fostering Dora and her puppies is I Heart Dogs. Consider an end-of-year donation, if you will.

By Orac

Orac is the nom de blog of a humble surgeon/scientist who has an ego just big enough to delude himself that someone, somewhere might actually give a rodent's posterior about his copious verbal meanderings, but just barely small enough to admit to himself that few probably will. That surgeon is otherwise known as David Gorski.

That this particular surgeon has chosen his nom de blog based on a rather cranky and arrogant computer shaped like a clear box of blinking lights that he originally encountered when he became a fan of a 35 year old British SF television show whose special effects were renowned for their BBC/Doctor Who-style low budget look, but whose stories nonetheless resulted in some of the best, most innovative science fiction ever televised, should tell you nearly all that you need to know about Orac. (That, and the length of the preceding sentence.)

DISCLAIMER:: The various written meanderings here are the opinions of Orac and Orac alone, written on his own time. They should never be construed as representing the opinions of any other person or entity, especially Orac's cancer center, department of surgery, medical school, or university. Also note that Orac is nonpartisan; he is more than willing to criticize the statements of anyone, regardless of of political leanings, if that anyone advocates pseudoscience or quackery. Finally, medical commentary is not to be construed in any way as medical advice.

To contact Orac: [email protected]

160 replies on “Take that, antivaxers! This is nearly the end…of 2017, that is—with puppies!”

Dora is gorgeous! She has the look of an old soul in her eyes. Those are some happy, healthy looking puppies you have there. Also, this post made me realize that I’m not following you on Facebook yet!
Happy New Year! As much as I enjoy reading your blog, I hope that nothing so egregious happens that you have to cut short your blogging vacation.

Oh, wow! They are adorable.

When my younger son was about eleven years old he got a dwarf hamster from a pet store. A few days later his younger sister and her friend went to see the hamster, and found about eight more tiny hamsters in the hamster cage!

The family needed more room, so we got more hamster habitats that connected together with tunnel tubes. They are nocturnal, so my poor son would occasionally wake up late at night to see me, his mom, lying on the floor watching the little critters scamper all through the habitats.

Orac and Ms O are truly admirable to do this. WOW! Lots of work.

I am always grateful to the people who provided foster care for my spectacular cat.
A cat gave birth under a porch in a small city: she was later killed by a car so the home owners- an elderly man and his daughter who foster pugs- found homes for two kittens immediately and took care of mine ( 2-3 weeks old), even getting him fixed. At 4 months, a worker in the vet’s office, took him home and to the foster system’s weekly shows at a pet store; later her sister took him ( who had dogs and cats) until I adopted him at 6 months.

He was raised with dogs and was extremely active and agile : I guess he HAD to be with dogs/ puppies.
Maybe that’s where he learned how to fetch.

Maybe that’s where he learned how to fetch.

My eldest cat, who was raised from a seed, was able to play fetch. Mini tennis balls and a 30 foot run were the key.

He was great at retrieving small rubber balls that you get from vending machines, putting them in your hand. Repeat for a half an hour. Someone I know feared that the balls were hazardous so I substituted soda straws- the cat would leap high for them. He’s slowed down a little but still loves to play-fight/ bite. Seeks out hidden objects; he does follow me around like a dog. Other cats never did. He understands and follows several commands like “SiT”, “COME HERE”,
“GO TO SLEEP”. Hasn’t got ” GIVE ME FOOT” totally yet, I’m working on it.

My cat is also somewhat puppy-like in that he follows me around. (Also rather like my two year old nephew.) No fetch, though, and he doesn’t seem to understand any English.

He was a stray that my mom started feeding, and he was kind of a scardey cat when I first encountered him, hence, in part, his name, Chicken.

At this point he is even friendly with strangers and will try to chase away other cats that show up. He is probably the sweetest, most affectionate cat I’ve met (sometimes it’s a bit much.)

(Yes, he’s been fixed and everything.)

That’s almost exactly our cranktail black tabby’s bio. Some neighborhood kids snaked the kittens out from under their porch when their mother got run over, went to the vet for formula and fed them, and found homes for all of them. Killer’s a little guy–never got very big–but he just loves everybody of whatever species. He’ll be 16 pretty soon, and is helping me type as I write this….erhihfttynjjj///////

At last you have displayed your true, arrogant, quackery based ways. You have gone from pharma shill to puppy mill and it is obvious that is all an attempt to distract . . . — oh, look, cute puppies! I, for one, welcome our new puppy overlords.

We are as good at running a puppy mill as we are as pharma shills. We’ve sunk a lot of time and a few hundred dollars into these puppies, whom we will be giving up to be adopted when they are old enough, which, sadly, will be fairly soon.

Where’s the profit in that?

Don’t blame me for the cat blanket.

Koff.* BTW, is that a Vienna sausage on the puppy’s leg, or was he just happy to see you?

Thanks for being part of the Grand Rescuial Band.

I’ve been putting in a lot of effort trying to socialize semiferal (and abused) cats and kittens lately to cool my head and have the scabs to show for it. May be superior to cryotherapy for treatment of verruca plana, if a hard sell.

^ Dammit, what’s with the eating of asterisks at the beginning of lines? There should be one before the final graf.

I don’t think I could do that. Puppies are easy by comparison. Yes, they poop a lot. Yes, they have pointy teeth and like to chew on clothes and digits. However, they are very social animals and, because we’ve had them since birth, have no…issues. At least, not yet, and I hope our fostering them doesn’t leave them with any. Also, they very much want to please. I think a couple of them might even be starting to learn recognize their names…

Dwarf hamsters are even easier than puppies. They don’t live very long though, so they gave the kids some real life lessons. Over two to three years we had a few small funerals. Le sigh.

Do you have any nieces or nephews living nearby that could us a new puppy? 😉

For a while we were on speed-dial with the local SPCA, whenever they came by a litter of feral kittens who needed socialising. The theory seemed to be that I’m barely half-domesticated myself, so I could provide a kind of halfway stage for them, It was a time full of satisfying accomplishments although my wrists now look like chopping-boards, covered with little white hairline scars.
Then one of the ferals decided to stay with us and she does not play well with others.

It was a time full of satisfying accomplishments although my wrists now look like chopping-boards, covered with little white hairline scars.

A couple of dozen minor hand wounds are probably not the best look for a surgeon to be sporting, now that I think about it again.

I’m so pleased you fostered a rescue dog.
Back in 1998, my family took in a Border Collie cross who would have been euthanased had we not given him a home. Jesse was a lovely dog.

Happy new year, from a long-time reader & fan.
If you vaccinate the puppies, will they get doggie-autism?

I knew a couple of people who were convinced their dogs were autistic.sigh In both cases I’d say under socialised, but what do I know?

I had a dog who was on the doggie autism spectrum, if such a thing exists. She was uninterested in dogs, cats, humans, or any creature other than my dad, and merely tolerated being petted.

She was, however, a good and smart dog, and we accepted her as a family member and kept her until old age. She was fully vaccinated… and treated with early anti-flea pills. That didn’t make her antisocial either.

“They also have to be introduced to solid food. ”

Including socks, shoes, and books.

Funny, just today there was a story in the Minneapolis Strib “Variety” section titled, “When Fido is sick as a dog, more pet owners turn to aromatherapy, massage, even psychics.” (What, no acupuncture or reiki?) I groaned, and resisted clicking on it. I trust though that Orac will be sure Dora’s pups go only to science-based fosters! 🙂

The hilarious thing is that the puppies, who all used to be able to fit on my lap, still seem to think that they are small enough to keep doing it.

We have learned that, with German Shepherds, this is a feature and not a bug.

Of that, I have little doubt. These puppies all weigh around 6-7 lbs each now (up from under 1 lb each at birth), but they still think that they’re tiny enough to fit on my lap the way they did three weeks ago. They all manage to pile on a bed that’s now a bit too small for them too, which is hilarious when they do it. It looks as though it would be uncomfortable, but somehow they make it work, and it’s cute as hell.

I knew a great dane that thought he was a lap dog. Sweetest thing. One time when I was at a sleepover at his family’s house he came to snuggle with me as I lay on the floor in a sleeping bag. He stretched down the entire length of my body.

He also had a habit of leaning on people he liked.

Back when Pontius was still an apprentice Pilate, I looked after our neighbors’ dog over Christmas one year. It was a beast of far northern heritage and substantial abundance, and he lived outdoors – a bull in a china shop being somewhat delicate by comparison.
I awoke on the night before Christmas with a very large furry bedfellow and my father standing at the door to my bedroom, splitting his sides with laughter. Dad had gone out to the garage to retrieve some hidden Christmas gifts and the dog had slipped by him, come into the house and down to my basement bedroom (how he knew where to go is beyond my ken). The dog apparently was trying to hide under me.


The mom of the family belonging to that lovely great dane told us about how he was a great help with solicitors. Someone would ring their doorbell, and she would answer with this huge dog behind her with his “are you my new friend?” face. Except all the solicitor would see behind her was a very excitable dog whose head was at her shoulder height.

The solicitors never stayed very long.

Unfortunately the lifespan of those lovely dogs is quite short. It is not much more than a hamster. It seems the bigger the mass and the sociability that is bred in, the more health issues also follow.

@ Chris
he was a great help with solicitors
My mind flashed to the UK and I had a vision of him gnawing on a lawyer’s leg.


Great danes are my favorites, especially blues like this one:

Unfortunately, it is still a work in progress to get one. Basically, I’d need a place to live with the dog (and a good paying job), a car (public transit is out of question with a dog that size) and maybe a few other thing that I haven’t tought off.


Here it is anyone who comes to your door, rings the bill and solicits for money for their business, your vote for their candidate, cash for their charity, your signature for their petitions or your faith for their religion.

Or it just means anyone who ignores the “No Solicitors” sign by the doorbell.

A friend of mine had an Irish wolfhound that thought he was a lap dog, she wasn’t tiny, but there are pictures of him on the sofa with just an arm or leg showing she’s under all that dog. Sadly he didn’t even get to live out what would have been a shortish life span as he got bloat and although she recognised the symptoms and rushed him straight to the vet who operated immediately he didn’t make it. Bloat is another thing larger dogs are more at risk from and although my two are only large, not giant, being German Shepherds I have made certain I know the symptoms.

Some of those big dogs are sneaky about getting on your lap. First they will rest their head on your lap, then it is one paw, and before you know it you are pressed against the back of the couch covered by dog.

Chris, my late Doberman was a total sneak like that. We’d done a massive cleaning of the carpets, which left him stressed out. Every time he thought he was safe, we’d rearrange the furniture to clean a new spot. By the time we were done, he was exhausted. He came over, plunked his head in my lap with a sigh and, after a couple minutes, there was a paw in my lap. A few minutes more, the other paw. Five minutes after that, 60 lbs of Doberman who desperately needed snuggles and comfort. I didn’t have the heart t kick him off as he just sighed with such relief when he plunked down on top of me.

This rule holds for Newfies, as I learnt when dog-sitting my then-boyfriend’s Bear, who outweighed me by 40 pounds but insisted on being a lap pup. He was also extremely mellow, and got along with the three cats I was fostering (and my own, not-speciest-atall cat, who even tolerated human toddlers who tended to interpret the tail as “handle”). Ditto for teacup saucer-eyed Mastiffs like the one that owns my mechanic. If I’m ever situated properly to be owned by another dog, I lean toward the biguns, despite the slobber. Although labs and lab mixes (and some smaller, yappier, bitey-er breeds) are irresistible too, I experience them as I do nieces, nephews, and grandchildren (theoretically speaking), that is, to be corrupted spoilt and given back to their parents.

Who knew that so many minions would be inspired by an adorable puppy video to mention cats.

It’s probably cultural but Newfies’ an insult around here in my province (like *tard) and every regular here know that, very often, threads evolved in vastly different directions so cats discussion in a dog thread does not register as offtopic.

Finally, I don’t remember reading the kfunk pseudo used very often but I do remember seeing it + I vague souvenir of it being used by Travis.

On the other hands, I’m knee deep into Brian Deer’s website and RI is next on my list so mental context switch have a good chance of throwing me off (i.e. making a mistake). Primary reason I haven’t been chasing sockies in the 4 last months even if sometime, I had doubts.


Puppies! Happiness is a warm puppy clip on the internet. Wish I could adopt one, but our ten year old lab cross is still a handful. Must be the vaccinations.?

We had a young dog that pulled off a baseboard from behind a radiator, blocking the kitchen door, and she chewed away a foot of the top of the moulding. We should have named her “BuzzSaw”.

We had a young dog that pulled off a baseboard from behind a radiator, blocking the kitchen door, and she chewed away a foot of the top of the moulding.

Heh. My aunt and uncle once adopted a St. Bernard puppy, who went on to happily live at the local fire department after a not-dissimilar remodeling of their kitchen.

I’m seeing some Labrador influence in the pups. Dora, hmmm…

Lab and maybe a bit of dachshund?

Anyway, congratulations!

I thought of you and the puppies (having seen them on FB) and Dora as we cruised through Detroit on our way to and from Toronto for Christmas. The videos are so cute and I sure wish we had those neat pens in my days of puppyrearing! We had to keep them in boxes or improvise with chairs and such. Luckily they were dachshund puppies and only three of them, but there were also three small children to complicate the commotion!

Thanks for sharing and have a very Happy New Year.

I think by fostering them out, you are losing a tremendous opportunity to have your very own “Dogs of War” to unleash on the anti-vaccine and pseudo-science nuts. A vicious fearsome pack of puppies to slobber all over your enemies. What more could a glowing box of lights need?

Congratulations on being owned by Dora, and best of luck letting go of the tiny terrors. I would foster if I dodn’t already know that I want to keep them all.

Looking at those puppies I think “Dogs of War” might be a bit of an exageration. I can see it now, “Famous anti-vaxer licked to death by rampaging pups”.

“He also had a habit of leaning on people he liked.”

A long, long time ago when we were still teenagers a friend and I did one of those crazy road trips, traveling everywhere. One fellow we visited had two dogs: a small terrier and not-quite a puppy anymore great dane. We had fun watching the smaller dog chasing the great dane around his large yard, then ignored them to chat.

When we’d first arrived I had petted the great dane and he apparently took a liking to me. He was a big dog that weighed substantially more than me. While the three of us were standing and talking I didn’t notice the great dane sidle up alongside me. Next thing I knew I was on the ground with a very surprised and very heavy dog on top of me. Yes, he had leaned against little old (young) me.

Apart from enduring the laughter from the others neither the dog nor I appeared to suffer any long term emotional scars.

My friend’s ( now ex) husband owned a series of large dogs ( Danes etc) but the one I knew best was an Akita. He liked to “dance with ladies”- which meant that this great big slobbering – but beautiful- mess would put his huge front paws on your shoulders and look soulfully into your face for as long as you could tolerate it, slow dancing. I’m 5’6″ so he would be at least my height when posed in this fashion. I believe that he weighed about 140 lbs.

My friend fed him a mix of canned and dry food with hot water, his “stew”, in a large mixing bowl which he would consume like a desperate, starved thing.
His other interesting habit was escaping and going for a run – especially towards and onto a busy local highway which necessitated people ( myself included) getting into their cars to search for him and trying to lure him in said vehicles. He liked the
bright lights, his owner said.

I also rescued a large yellow Lab, Spy, who was similarly inclined several times ( different owner).

My aunt breeds rough collies. At least three of them, all related,thought they were lapdogs. Which is kind of uncomfortable when the dog is easily fifty pounds, with half of that being hair. Some of them like to jump, too, and one will sneak up behind people and jump on their backs.
That said, she hasn’t had puppies in a while, and I miss that. A small friendly wolf pack, bumbling across the yard, determined to untie all shoe laces and lick everyone they encounter to death. I hope Orac’s bunch find good homes- also, don’t worry Orac: puppies that get plenty of love and play and warmth do just fine.

Some of them like to jump, too.

You have not experienced the joys of mammals who think they’re parrots until the cat sequestered in your bathroom for anti-social attitudes toward your constant companion of 15 years goes from ounces to kilos, with claws, when you’re trying to exit the necessary room.

From her POV, it’s fortunate to be a lone cat, now. She has the run of the house and is entirely treated as a felid. Plus she’s a tool-user: periodically, she still flushes the toilet 30 or 40 times in quick succession to get my attention.

Orac writes in the title,

Take that, antivaxers!

MJD says,

What does “antivaxers” encompass?

I’ve asked you to provide a definition for “antivaxer” many times and you’ve failed/refused to respond.

Can you enlighten us and define “antivaxer” in 50-words or less?

Q. How are puppies like respectful insolence.

A. Cute but messy

@ MJD:

Don’t you get it? You’re out of your league!
Although many minions have already told you, it bears repeating:
your analysis of complex issues is incredibly simplistic and your attempts at levity ill advised and juvenile.

Because you read a few article about the brain or computers, doesn’t mean that free associating concepts you discovered therein willy nilly makes any meaningful criticism .
Pedestrian, prosaic and parochial come to mind as adjectives for your commentary. I left out plodding.
We often ridicule Teresa Conrick’s “science”- she’s a few grades above you although just as wrong.

Orac is extremely tolerant- he needn’t answer to you..

Take a few courses in psychology and biology at a county college. I know you have a degree BUT,,,,

Dear Denice,

Dunning Kruger + alternate reality + alternative perception of alternate reality == MJD



Well I could use the same equation about the gnat and his biochemistry12 girlfriend below 😀


It seems my comment fell upon deaf ears ( MJD)

Theory of mind…as someone, somewhere on this planet say :S

Alain <– who’s supposed to be autistic 😀

Alain writes,

It seems my comment fell upon deaf ears ( MJD)

MJD says,

In this forest of respectful insolence, I often feel like a rabbit being chased by a pack of wolves and you’re the Alpha Male.

I’m weary, please call off the wolf pack until 2018.

I’m weary, please call off the wolf pack until 2018.

I’m spending half of my days in front of the porcelain god that is commonly called a toilet, “praying” that whatever causes my stomach bug stop causing such stomach bug (or consequence..)

I’ll take the decision later. In the meantime, keep running.


MJD; “Can you enlighten us and define “antivaxer” in 50-words or less?”

Orac? Under 50 words? Unlikely. That’s why I keep reading.

Me, on the other hand?

If you argue against the use of vaccines on the internet, you are antivaccine and therefore an “antivaxer.”

18 words. Enjoy!


Since there are three M’s in Chemmomo how about “3M” as the new nym?

@ 3M,

If you spew respectful insolence on the internet about vaccine safety advocates, you are one of “Orac’s minions”.

18 words, Enjoy!

18 words, Enjoy!

Twice. Anyway,

If you argue against the use of vaccines on the internet, you are antivaccine and therefore an “antivaxer.”

That is a keeper.

Alain, Shay, Chemmomo:

It seems my comment fell upon deaf ears ( MJD). I am better understood by large tabby cats, beginner ESL/EFL students, dining room tables and random credenzas.

Anyway, we must put forth a united front against nonsense,

In other wacky pet news…

My cousin’s widow adopted a Shih Tzu- Yorkie ( Shorkie) 6 months ago, About a month ago, the puppy began chewing on connections/ pipes of appliances made of plastic and METAL. She tried various bitter products but the dog persists so she has to resort to putting her in a crate whenever she leaves the house ( which she wanted to avoid doing) She teaches so she’s only gone for a few hours at a time (home for lunch). This started before school holidays. Nothing else new has happened there. The dog trainer called it separation anxiety.

I studied a bit of animal psych..but I can’t even guess.

Hey you gossiping wootards. Did you hear about Jake Crosby? I heard that he’s now promoting the aluminum etiology.

Which could, of course, increase histamine‐releasing mast cells in the brain. Although biosynthesis from the tuberomammillary nucleus (dependent on dietary histamine over sum of competing amino acids) is generally thought represent the extent of this neurotransmitter, researchers have determined—in the rat at least—that mast cells can account for 90% of total brain histamine. In every trial this has been tested on—from using histamine itself, its antagonists such as cimetidine, tuberomammillary ablation, and histadine decarboxylase inhibitors—histamine has been shown to decrease learning, have antinociceptive properties, and decrease social interaction. Schizophrenics have been found to have levels 2.6× the histamine concentration of controls—a neurotransmitter antagonized by acetylcholine (perhaps explaining the ~5× increase in smoking found among schizophrenics). This is ostensibly from immunogenic proteins such as gluten, which can both explain the high histamine levels and consistent findings of high gluten exorphins in the cerebospinal fluid in patients having this condition. The celiac intestine has ~3× the mast cells of controls, and fluorescent‐labeled mast cells have been proven to migrate to the brain.

There is great interpersonal variation in brain mast cells, ranging from zero to thousands. As the single neurotransmitter exhibiting the highest range, histamine should certainly not take a backseat to serotonin—or opiates, nor glutamate: neurotransmitters historically implicated in the etiology of autism and schizophrenia by lesser people.

“…gossiping wootards. Did you hear about…”

Your credibility score had been zero. Congratulations on dropping into negative territory.

Do you have a puppy nearby to console you?

Your credibility score had been zero. Congratulations on dropping into negative territory.

Travis is usually pretty prompt with that sort of thing.

Dora is not merely good looking she is also one smart dog. Not only did she apparently pass the surgery recertification boards (I’d love to see a photo of her exam disguise), after reading the Xmas cards delivered to your home she decided on a seasonal eight puppies: Dasher, Dancer, Prancer, Vixen, Comet Cupid, Donner, and Blixen…

Our childhood dog was a Welsh Springer Spaniel. When she had seven puppies they all got Welsh names. The only ones I remember now are Dylan and Myfanwy. Dylan had been renamed Fluffy by his heathen, Philistine owners when we met them on a walk a few years later.

Some more good news.
Doug Jones has been certified the winner in the Alabama Election.

Democrat Doug Jones’ historic victory over Republican Roy Moore was declared official on Thursday as Alabama election officials certified him the winner of the special Senate election, despite Moore’s last-minute lawsuit claiming voter fraud.

@ Julian Frost:

I looked at details of the voting:
one of the reasons Mr Jones won is because African Americans came out in LARGE numbers – IIRC even more than they did for Obama in his elections – they are a significant minority ( 26%?) of the electorate even though efforts have been made to limit their participation ( voter ID rules especially).

Also, it’s likely that many regular republican voters in “red” counties sat out the election because of disgust with Moore.

Like we learned with Trump in places like the traditionally blue Midwest ( Michigan, Ohio, Wisconsin) and in Pennsylvania,
unexpected things can occur.

I hope that 2018 will show increased participation by all voting groups.

“He does NOT deserve a puppy.”

I think what you meant to say is that no puppy deserves him.

I just celebrated my second Gotcha Day with my rescue, Juno. She’s a Carolina Dog, the only native breed of dog in the lower 48. She was a neglect case; her owners adopted her as a puppy but banished her to the backyard when they adopted a baby four years later. She was dreadfully underweight, and while her foster did get some of that back on her, she was still thin when I got her.

She’s an incredibly sweet, smart dog. Bladder of steel, never chews, well trained, well behaved. For the life of me I can’t get why her owners let her get away from them. She’s a great dog. And I’m very lucky.

My cat, Taz, I got as a kitten from the shelter. Never spent time around dogs until I got Juno, but she enjoys a good game of fetch, which Juno doesn’t (tag of war is her thing). They make life interesting and fun 🙂

Dog flu is going around my area. When the vaccine became available, you better believe I got it for her. No signs of autism yet. She did sleep most of the day after the shot.

Panacea writes,

Dog flu is going around my area. When the vaccine became available, you better believe I got it for her. No signs of autism yet.

MJD says,

Your understanding of typical and atypical canine behavior is simply too limited, Panacea.

Enough said…

Your understanding of typical and atypical canine behavior is simply too limited, Panacea.

No, Michael. Your understanding of and ability to detect sarcasm is what’s limited.

Chemmomo: “If you argue against the use of vaccines on the internet, you are antivaccine and therefore an “antivaxer.”

You forgot to add, ‘if you have unrealistic standards of safety, you are probably an anti-vaxxer.’

I mean, seriously, anti-vaxxers demand less from their cars. They’d be happy to drive flaming pintos. One person gets into a car accident after having a vaccine, and they’d blame it on the vaccine, rather than looking at the weather, the type of car (s) involved, or the drivers. Or for that matter, the hundreds of other people who didn’t get into a car accident that day.

Best New Year’s wishes to all the Insolence Rat Pack (or puppy pack). Remember, after a hard night’s partying you’ll want to Detox with a pint of genuine organic non-GMO apple cider vinegar, which also is good for:

Supporting Weight Lost (sic)

Protective Effects Against Cancer

Lowering cholesterol

Preventing Indigestion

Boosting Energy

Controlling Blood Sugar

Reducing Nighttime Leg Cramps

Start your “journey” today!

Alain: By “girlfriend” did you mean ‘Jake’s right hand?’ or “Milo Yanniopolis?” Because if Jake actually had a real live girlfriend, either his mother figured out how to make statues live, or the police need to look into that.

None of these answer, I meant Travis who posted as biochemistry12 and who, at one time impersonated me on the gnat’s blog (one of the blog post about transgender).

Travis and the gnat, they make a nice couple 🙂

Al (still praying in front of the porcelain god, not as often).

I meant Travis who posted as biochemistry12 and who, at one time impersonated me on the gnat’s blog

Oh, I missed this. That floating stool pulled the same thing with my name at AoA.

I don’t recall the exact words (and finding that post is a bit difficult now that the gnat is prolific) but the gnat even did me the honor (sarcasm alert!) of calling me Elaine 😀


Happy New Year, sceptics, shills and minions
( and our esteemed leader and Master of Puppies, Orac – and Second in Command, Ms O, of course):

It appears that we have a lot of work ahead of us because like rust, woo never sleeps ™

I unfortunately listened to a new year’s broadcast of null sense and read Mikey’s latest predictions :
they both agreed that HARD TIMES are ahead for nearly everyone
( except for the super rich who will live in green zones far from the madding crowd, earthquakes, fires, hurricanes, poverty, race riots, unemployment, GMOs, police states, toxins, mercenary physicians, pharma, fluoride, vaccines etc.)

there will be a financial collapse in ” 24 months” and war with North Korea! Same as last year.

I suppose they have survival products and videos on organic gardening to sell.

I decided against looking at whatever swill was spouted by AoA, TMR, Jake and similar loathsome venues because I am not after all, a super being- I have limits.

At any rate, I send my regards and best wishes for a productive and happy 2018 to everyone concerned about the frightening encroachment of woo, pseudoscience, altie BS, fake news and misinformation on the internet!

It’s up to us to fix it!!
We meet HERE!

I decided against looking at whatever swill was spouted by AoA

Yah. I mean, I decided on short notice to cook for a couple of friends for yesterday, so I’ve been moving quite slowly today (despite having to run all over the place before the open stores close), and now, just having my first cup of coffee, I find this from Gus the Fuss:

Bitcoin and vaccines?We have all the criminals Gates Soros et-al with all the spoils from harming our kids and harming the world wide populations of the world.So what I believe is that there is a big rush to get some of the ill gotten gains hidden before Trump does a Saudi purge and confiscates all the ill gotten gain’s back from the monster criminals and slam them in the slammer.Hence the rise in Bitcoin which I beilieve is harder to track and trace who owns what.Trump will take the ill gotten gains back and pay off the money unaccounted for at the Pentagon and the lesser official national debt.How many billionaires will it take to do that ,not many.As we all know on here there are a few at the top making a pile of money whilst nations are starving and dying and being controlled and being made nonfunctional through vaccine induced disabilities these abuses are about to be punished.

This article below describes as above but its not where I get my info from on this…

Pharma for Prison



Anybody who can make sense of this is made of sterner stuff than I am.

Assuming the product works as described and follow-up studies confirm that, it would be conventional medicine.

@ Mephistopheles O’Brien,

Wouldn’t it also be considered integrative medicine in that the provider uses a natural and less invasive healing science (i.e., shock waves) to facilitate the body’s innate healing response?

a natural and less invasive healing science (i.e., shock waves)

“Natural”? “Less invasive” than what? Did you even read your own blurb?

@ Narad,

Don’t get this type of integrative medicine “shock wave” confused with an Earthquake. 🙂

Orac: I just had a thought. Some of those puppies look like dalmation mixes. Make sure the puppies have their hearing tested before they leave for new homes, since deafness is a common problem for dalmations.

Alain: None of these answer, I meant Travis who posted as biochemistry12 and who, at one time impersonated me on the gnat’s blog (one of the blog post about transgender).

Oh, I missed that in the chaos leading up to the holidays. Then again, I don’t look at Jake’s blog at all. I’m trying to bring my blood pressure down.

Hope you feel better soon. Something like that was going around my family in November. Since we precelebrated Thanksgiving, we skipped it on the actual day, due to not being equipped to deal with solid food. (Comparing notes, we’re pretty sure we caught it at the precelebration.)

Stomach bug,

I ate at my cousin’s place last Saturday. He has the habit of thawing frozen items on the countertop or on top of the clothes dryer. Bugs and other creature absolutely love his habit.

Oh no! I hope you feel better soon. I say as I am about to toss Christmas dinner leftovers.


I definitely did not get drunk since Saturday night but I sure wish I could.


He has the habit of thawing frozen items on the countertop or on top of the clothes dryer.

Dare I ask what he was defrosting? Perhaps it’s just me, but most people I know with in-home clothes dryers also have running cold water available, as well as microwave ovens.

Those would be things I would be very, very carefull with. Not thawing them outside the fridge. The same with chicken.

I would be careful with those also. When I get a bag of frozen scallops I repack them three to four in a small closable plastic bag (I am the only one who eats them in this house). When I want to eat some scallops I just take one of the little bag, and put them in a bowl of water for about ten to fifteen minutes. Then finish thawing in the fridge. Dry them off and fry quickly.

Dear G-d, and he manages storage of shellfish? Cold. Running. Water. I once had to do a turkey in the bathtub, but your tale is amazing.

That’s what happen when one’s $DAYJOB require him to work over 50 hours per week of heavily physical work and he arrive home, drained out.

I did try to instill some good home skills but it’s rinse, lather, repeat. He’s slowly learning, veeerrrry slowly.

Alain (feeling better today, I can eat).

Ugh. Countertop I’ve done, but I keep a clean place, and make sure to keep an eye on the food. But clothes dryer? Seriously?

“If you can figure out how to bottle puppy breath, you will make millions.”

You are obviously a pharma shill. It’s far healthier to experience puppy breath the way nature intended.

My lab Friday, in the 90’s, (named after Heinlein’s Friday) gave birth to 16 puppies. What an amazing time. Trying to keep all the pups fed was hard work, I started them on puppy chow mush at about week old.

By time they were 8 weeks old they weight 30 lbs or so. They were all escape artists, what joy it was trying chase down all those pups. Luckily they ran as a pack.

Friday at times thought she was a lap dog and would launch herself from across the room to land in my lap. Oh, she weighted 90 lbs, no fat.

She was a great dog, retrieved her first duck at 5 months old. I still miss her to this day.

Happy New Year to everyone. I have only 18 days to retirement and 28 days until I move to Thailand.

I don’t think you should pick on Jake anymore, he’s a nice guy. I think instead we should all start reading more about cytokines, histamine, phosphorylated microtubule‐associated proteins, aluminum, mast cells, and inclusion bodies.

Immune activation shouldn’t last decades, from one vaccine, but you’d think a persistent response could be induced by aluminum inclusion bodies and/or phosphorylated microtubule‐associated protein–aluminum conjugates. Cytokines have been associated with neurofibrillary tangles, and neurofibrillary tangles have been associated with aluminum. Persistent immune activation can attract thymus cells—which can migrate to the brain and release cytokines. This can induce nitric oxide synthase, which has psychoactive potential. Also: interferon-γ can induce tryptophan dioxygenase, the induction of which can lower circulating tryptophan levels by ~50%. Fernstrom readers out there know what this means; it has been shown that brain serotonin synthesis correlates strongly with plasma tryptophan over the sum of competing amino acids (T, V, I, L, F).*

So persistent interferon-γ release from T cells, and mast cell induction from peripheral inclusion bodies, can lead to the sort of psychology characterized by the schizophrenic—or the grain eater who doesn’t eat enough tryptophan to counter tryptophan dioxygenase.

Perhaps ORAC can tell us about the presentation of celiacs, and either deny or confirm any characteristic psychological findings.

‘Inflammation clearly occurs in pathologically vulnerable regions of the AD brain, with increased expression of acute phase proteins and proinflammatory cytokines which are hardly evident in the normal brain [20–23].’ ―Rubio-Perez‡

Neurofibrillary tangles have been shown to be induced by injection of aluminum chloride, on multiple occasions—in multiple species.§

[*] No people, (T, V, I, L, F) is not an acronym for transvestite I’d like to ƒ**κ, those are one‐letter amino acid codes representing tyrosine, valine, isoleucine, leucine, and phenylalanine (which gets an ‘F’ not because it failed, but because the ‘P’ is reserved for proline—a most unusual amino acid.)
[†] I thought about Tim Curry just now, for obvious reasons.
[‡] Rubio-Perez. “A review: inflammatory process in Alzheimer’s disease, role of cytokines.” The Scientific World Journal (2012).
[§] Yates, Celia. “Neurofibilary Degeneration Induced in the Rabbit by Aluminum Chloride: Aluminium Neurofibrillary Tangles.” Neuropathology and Applied Neurobiology (1976)
[¶] ⟵Pilcrow baby. A fμcking pilcrow! How cool is that?

I don’t think you should pick on Jake anymore, he’s a nice guy

Göring, although not comparable in deed, was also a nice guy…


Happy new year, people. Here is a tribute to turning the frekkin’ frogs gay in 2018.

Then I’ll have to post more cute puppies videos soon. The puppies will be going back to the shelter on Sunday to be adopted out to forever homes, and after that my supply of cute puppy videos will dry up. I expect that the puppies will be adopted out pretty fast because they’re so damned cute. I will definitely miss those cute little buggers something fierce, but they are getting to be a real handful to take care of now.

Have they had a chance to play in the snow?

Also, I hope your basement has a shower and you have a set of downstairs versus upstairs clothes. I kind of do this with certain kinds of gardening, like planting fall bulbs in the rain.

I have to admit, ORAC, that picture is astoundingly good. I think you’d be able to sell some pictures of that dog, if you needed the money (I did hear about that plane ticket, must be tough).

I have seen a few pictures of dogs, and even puppies, but yours is particularly . . . cute—if I dare use a word so femininizing. (…and then his small manboobs grew thee sizes that day.)

Gosh, those pups are cute! If this was a Facebook post I’d definitely give it a . I can see where they’d get to be a handful, though… I am a cat lady, but I like dogs too and have always said I’d have one if I had the living space. She (Mama) is cute, too. Looks friendly and sweet. Best of luck with all of them.

Right now Mikey is too busy predicting the end of the world as we know it and scaring his fans away from legal pot in California
because it’s contaminated with mold, pesticides, metals and chemicals.
Maybe he just wants them to send in samples for his famous testing lab.

Mike of course would never smoke any.

biochemistry12: “I don’t think you should pick on Jake anymore, he’s a nice guy.”

Hahaha, no. He’s an idiot, a misogynist, a homophobe and very probably a racist. He thinks the sun shines out of Wakefield’s and Trump’s butts. He’s nearly 30 and can’t figure out how to be human. Most people have some social skills by that age, autistic or not. Honestly, you’re only supporting my theory that you are, in fact, a sockpuppet. Even if you’re not, you’re still stupid.
I see a lot of words in your post, but no indication that you know what they mean. I think you’re quoting Shaw and Tomljenovic, and as pointed out above, the paper, as all their previous papers were, has been retracted. In other words, the editors do not believe the paper has any basis in fact.

Also, I’m not sure if you’re aware that some vaccines do not in fact last decades. DPT lasts maybe ten years. I’d like to point out that if certain diseases confer immunity for life, why is it wrong to get the same immunity from a slightly different and kinder source? (You ever had chickenpox, dork?)

I am not quoting anyone. I had come to my conclusions after reading dozens of articles on the topic and can prove every word that I say. Perhaps you should ask for clarification if there is something you’re having trouble comprehending.

You had misrepresented my post, ostensibly because you’re ignorant.

I wasn’t talking about antibodies; I was talking about cytokines, tryptophan diooxygenase, and mast cells. I really doubt that and enzyme will remain induced ten years after a vaccines. Antibodies themselves are relatively harmless; the real danger is with the cytokines—or specifically, the enzyme’s they induce.

So are you going to keep spinning your propeller hat or can you say something of significance?

I had come to my conclusions after reading dozens of articles on the topic and can prove every word that I say.

You were asked already to provide supporting evidence and failed.
To paraphrase a well-known internet comment:
Proof, or GTFO.

biochemistry: “You had misrepresented my post, ostensibly because you’re ignorant.”

LOL. I’m not the ignorant one here, dude. Perhaps you should try reading an actual scientific journal sometime, not the pay-for-play bottomfeeding journals your kind favors.

I have read over one thousand such articles, many from the bests journal: The Journal of Biological Chemistry

Why don’t you go grab your club and go back to your cave. I don’t think you have anything to contribute besides grunts, red herrings, and strawmen.

Look Julian, I had said before that no one article provides ‘proof.’ What exactly do you wan’t to know? I can show you experimental evidence for the entire concept, but only one step at a time.

It would take me all day to lay down all of the experimental, clinical, and epidemiological evidence. You can ask me to support one claim at a time, or do your own reading—or do nothing, and keep pretending that autism is genetic so you can keep eating pizza.

Start with this one.

Hey you gossiping wootards. Did you hear about Jake Crosby? I heard that he’s now promoting the aluminum etiology.

Which could, of course, increase histamine‐releasing mast cells in the brain.

Provide evidence that aluminium adjuvants actually DO increase histamine-releasing mast cells in the brain.
Then this one.

…researchers have determined—in the rat at least—that mast cells can account for 90% of total brain histamine.

Show good evidence that this has been replicated in large scale studies in HUMANS.

Julian, maybe he can tell us exactly how pizza ( not genetics) causes autism-
is it the gluten or the casein or both?

It would take me all day to lay down all of the experimental, clinical, and epidemiological evidence.

Well, you’ve had since November 7 to put some content on your “blog.”

Has anyone come across this coming antivax scamfest? It looks like an AutismOne road-show.

I came across it while checking out not-doctors Jeff Senechal and Randy Tent, who together are “Diverse Health Services” and sell (inter alia) the “GlycoPlus” placebos from Thom and Candice Bradstreet… who have spent the last few years exploiting their relationship to the late unlamented Jeff Bradstreet (in a fitting tribute to his career of fraudulence and grifting).

bimler, that’s a new one – and a new cast of woo-meisters – for me,

Mast cells are increased in the celiac intestine roughly threefold,⁽¹⁾ and have been shown to migrate to the brain in rats⁽²⁾ where they can account to roughly 90% of total brain histamine.⁽³⁾ Concentrations of mast cells can range significantly—from zero to thousands.⁽³⁾ Casein also has a few enzyme resistant proline–glutamine repeats,⁽⁴⁾ although less immunogenic than gliadin. Histamine has been shown to decrease learning in rats in at least four different ways: tuberomammillary ablation,⁽⁵⁾ inhibition of histamine decarboxylase,⁽⁶⁾ cimetidine receptor blockade,⁽⁷⁾ and through the injection of histamine proper.⁽⁷⁾ All of these studies show the same trend.

There’s tons of proof out there if you’re interested; but I suspect you’d feel better abut yourself clutching to dubious genetic associations, weak methylation hypothesis, and sociological explanations with little merit—basically everything that has nothing to do with vaccines.

The funny thing is: nobody here will actually read these studies, besides perhaps Dochniak.. . .

I’m fairly certain that anyone who examines this issue in an unbiased manner will come to similar conclusions.

[1] Strobel, S. “Human intestinal mucosal mast cells: expanded population in untreated coeliac disease.” Gut (1983)
[2] Silverman, Ann-Judith. “Mast cells migrate from blood to brain.” Journal of Neuroscience (2000)​
[3] Goldschmidt, Robert C. “Rat brain mast cells: contribution to brain histamine levels.” Journal of neurochemistry (1985)​
[5] Segura-Torres, Pilar. “Tuberomammillary nucleus lesion facilitates two-way active avoidance retention in rats.” Behavioural brain research (1996)​
[6] Sakai, Naruhiko. “Depletion of brain histamine induced by α-fluoromethylhistidine enhances radial maze performance in rats with modulation of brain amino acid levels.” Life sciences (1998)​
[7] Eidi, Maryam. “Effects of histamine and cholinergic systems on memory retention of passive avoidance learning in rats.” European journal of pharmacology (2003)

What is this Imler-bay whereof you speak?
Following the twists and turns in the GcMAF market is probably evidence of too much time. First the market was dominated by the ‘MAFActive” products, from Lesley Hutchings. Then she disappeared from the scene after persons unknown dobbed her into the French authorities, under mysterious circumstances, though her business rivals were all very sympathetic.
See e.g. here:

So the field was free for Candice Bradstreet with her “GlycoPlus” products. She has divvied up the US and Canadian markets between a couple of like-minded friends, and also supplies not-doctors Senechal and Tent on the side.

Mast cells are increased in the celiac intestine roughly threefold…

Coeliac/celiac is not a cause of autism. I therefore can’t see why you chose cite 1.

…and have been shown to migrate to the brain in rats…

In rats. I wanted proof that this occurred in humans.

…where they can account to roughly 90% of total brain histamine.

Still rats, no humans so far.
From your Cite [4]:

Casohypotensin acts as a bradykinin-potentiating peptide. Induces hypotension in rats.

Rats, not humans.
Studies 5-7 also mention rats.
What you have is plausible, but not convincing. As I asked in point 2, show us proof that this occurs in humans.

Also, none of your cites contain evidence that aluminium can induce mast cell production or celiac/coeliac disease, so what you have given us so far is tenuous.

I saw the post, but I didn’t check the author’s name. I thought the style was awfully similar. Me maxima culpa.

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