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Cancer Clinical trials Medicine

Evangelos Michelakis on dichloroacetate (DCA) and glioblastoma

As a followup to my rather “epic post” on dichloroacetate, I thought I’d just post a brief follow up. A reader sent me this video of Evangelos Michelakis, the investigator who has been testing DCA in the clinic and who did the study testing DCA against gliblastoma, describing his results: It’s always interesting to hear […]

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Cancer Clinical trials Medicine

Dichloroacetate (DCA) and cancer: Déjà vu all over again

Late last week, a crank I hadn’t heard from in a while showed up in my comments. I’m referring to DaveScot, who normally was known for promoting anti-evolution rhetoric in the service of the pseudoscience known as “intelligent design” creationism. This is what he said: Hi Orac, terrasig suggested you do a followup article on […]

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Bioethics Cancer Medicine

Dichloroacetate and cancer: Health scammers never die; they just keep popping up like Whac-A-Mole

It’s been a long time, been a long time, Been a long lonely, lonely, lonely, lonely, lonely time. – Led Zeppelin Not nearly long enough. – Orac Some rats never die, it would appear. You may recall last year, when I spend a considerable amount of verbiage writing about a promising cancer drug called dichloroacetate […]

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Cancer Clinical trials Medicine

Dichloroacetate to enter clinical trials in cancer patients

I’ve written a lot about dichloroacetate, a.k.a. DCA (my last post here, along with links to my previous posts), the small molecule drug that burst onto the scene after Evangelos Michelakis of the University of Alberta published a paper in Cancer Cell in January describing strong anti-tumor activity in preclinical models (in this case, a […]

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Bioethics Cancer Clinical trials Complementary and alternative medicine Medicine Quackery

An “arrogant medico” makes one last comment on dichloroacetate (DCA)

I love it. You see I noticed an old “friend,” the Herbinator, making this comment about me regarding dichloroacetate: I was listening to CBC Radio – the Current, as is my want, and there was a show on about DCA, or Dichloroacetic acid. DCA is a molecule so simple and cheap to make that drug […]